Inflamatory Changes in Laryngeal Mucosa in Rats Due to Acid, Nitrite and Pepsin Exposition
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چکیده
منابع مشابه
Effect of concomitant administration of eicosapentaenoic acid and alendronate on bone changes due to methylprednisolone in rats
One of the main limitations of glucocorticoid therapy is its negative effects on bones. The aim of this study was to determine the effects of concurrent administration of eicosapentaenoic acid (EPA) and alendronate on bone changes induced by glucocorticoid treatment in rats. Thirty six male Wistar rats, who were 2.5 months of age, were divided equally into six groups and treated with normal sal...
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Laryngopharyngeal or gastroesophageal reflux is associated with laryngeal airway hyperreactivity (LAH), but neither the cause-effect relationship nor the underlying mechanism has been elucidated. Here we established a rat model with enhanced laryngeal reflex reactivity induced by laryngeal acid-pepsin insult and investigated the neural and hydroxyl radical (*OH) mechanisms involved. The larynge...
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The pathogenetic mechanisms of laryngeal airway hyperreactivity (LAH) in patients with extraesophageal reflux are unclear. We recently reported that a laryngeal acid-pepsin insult produces LAH that is mediated through sensitization of the capsaicin-sensitive laryngeal afferent fibers by reactive oxygen species (ROS) in rats. Since ROS may promote the release of ATP from cells, we hypothesized t...
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Methods The study was performed on 20 New Zealand white rabbits, distributed into two equal groups. In the case of the first group of 10 experimental animals, we induced the model of ipsilateral double obstruction, the opposite side being left intact as term of comparison. Thus we produced the mechanical obstruction of the nasopharynx at the level of the choanal orifices as well as the obstruct...
متن کاملOccupational rhinitis due to pepsin.
A woman presented work-related rhinoconjunctivitis due to inhalation of pepsin used in a slaughterhouse. Prick tests and conjunctival challenge were positive to pepsin. Serum specific IgE to pepsin was 5.58 kU/L and an IgE-binding band of 43 kDa was detected in SDS-PAGE Immunoblotting. Rhinoconjunctivitis improved clearly when the patient was assigned to another place without contact with pepsi...
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ژورنال
عنوان ژورنال: British Journal of Medicine and Medical Research
سال: 2014
ISSN: 2231-0614
DOI: 10.9734/bjmmr/2014/3293